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Structure paper

TitleRole of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 146, Page 471-, Year 2011
Publish dateNov 25, 2010 (structure data deposition date)
Authorsvon Kleist, L. / Stahlschmidt, W. / Bulut, H. / Gromova, K. / Puchkov, D. / Robertson, M.J. / MacGregor, K.A. / Tomilin, N. / Tomlin, N. / Pechstein, A. ...von Kleist, L. / Stahlschmidt, W. / Bulut, H. / Gromova, K. / Puchkov, D. / Robertson, M.J. / MacGregor, K.A. / Tomilin, N. / Tomlin, N. / Pechstein, A. / Chau, N. / Chircop, M. / Sakoff, J. / von Kries, J.P. / Saenger, W. / Krausslich, H.G. / Shupliakov, O. / Robinson, P.J. / McCluskey, A. / Haucke, V.
External linksCell(Cambridge,Mass. ) / PubMed:21816279
MethodsX-ray diffraction
Resolution1.69 - 1.7 Å
Structure data

PDB-2xzg:
Clathrin Terminal Domain Complexed with Pitstop 1
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4g55:
Clathrin terminal domain complexed with pitstop 2
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-VH1:
2-(4-AMINOBENZYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONATE

ChemComp-HOH:
WATER

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-VH2:
N-[5-[(4-BROMOPHENYL)METHYL]-4-HYDROXY-1,3-THIAZOL-2-YL]NAPHTHALENE-1-SULFONAMIDE

Source
  • homo sapiens (human)
KeywordsENDOCYTOSIS / ENDOCYTOSIS INHIBITION / Beta-Propeller

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