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-Structure paper
Title | VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. |
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Journal, issue, pages | J Infect Dis, Vol. 212, Page 1439-1448, Year 2015 |
Publish date | Jul 14, 2012 (structure data deposition date) |
![]() | Lepesheva, G.I. / Hargrove, T.Y. / Rachakonda, G. / Wawrzak, Z. / Pomel, S. / Cojean, S. / Nde, P.N. / Nes, W.D. / Locuson, C.W. / Calcutt, M.W. ...Lepesheva, G.I. / Hargrove, T.Y. / Rachakonda, G. / Wawrzak, Z. / Pomel, S. / Cojean, S. / Nde, P.N. / Nes, W.D. / Locuson, C.W. / Calcutt, M.W. / Waterman, M.R. / Daniels, J.S. / Loiseau, P.M. / Villalta, F. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.83 - 2.05 Å |
Structure data | ![]() PDB-4g3j: ![]() PDB-4g7g: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-VNT: ![]() ChemComp-HOH: ![]() ChemComp-VFV: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / cytochrome P450 fold / heme / monooxygenase / sterol biosynthesis / eukaryotic membrane biogenesis / cytochrome P450 reductase / endoplasmic reticulum membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |