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Title | Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 5003-5012, Year 2012 |
Publish date | May 14, 2012 (structure data deposition date) |
![]() | Norman, R.A. / Schott, A.K. / Andrews, D.M. / Breed, J. / Foote, K.M. / Garner, A.P. / Ogg, D. / Orme, J.P. / Pink, J.H. / Roberts, K. ...Norman, R.A. / Schott, A.K. / Andrews, D.M. / Breed, J. / Foote, K.M. / Garner, A.P. / Ogg, D. / Orme, J.P. / Pink, J.H. / Roberts, K. / Rudge, D.A. / Thomas, A.P. / Leach, A.G. |
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Methods | X-ray diffraction |
Resolution | 2.05 - 2.55 Å |
Structure data | ![]() PDB-4f63: ![]() PDB-4f64: ![]() PDB-4f65: |
Chemicals | ![]() ChemComp-0S7: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-0S8: ![]() ChemComp-SO4: ![]() ChemComp-0S9: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / ATP binding / phosphorylation / trans-membrane / TRANSFERASE-TRANSFERASE INHIBITOR complex |