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TitleDown-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 28840-28851, Year 2012
Publish dateMay 3, 2012 (structure data deposition date)
AuthorsZhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Zeng, L. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. ...Zhang, G. / Liu, R. / Zhong, Y. / Plotnikov, A.N. / Zhang, W. / Zeng, L. / Rusinova, E. / Gerona-Nevarro, G. / Moshkina, N. / Joshua, J. / Chuang, P.Y. / Ohlmeyer, M. / He, J.C. / Zhou, M.M.
External linksJ. Biol. Chem. / PubMed:22645123
MethodsNMR (solution) / X-ray diffraction
Resolution1.4 Å
Structure data

PDB-2lsp:
solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide
Method: SOLUTION NMR

PDB-4f3i:
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-0S6:
methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / NF-kB / BRD4 / HIV / bromodomain / kidney disease / SIGNALING PROTEIN/INHIBITOR / protein-inhibitor complex / acetyl-lysine binding / nucleus / SIGNALING PROTEIN-INHIBITOR complex

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