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TitleRecognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 33123-33131, Year 2012
Publish dateMay 8, 2012 (structure data deposition date)
AuthorsMa, J. / Tang, W.K. / Esser, L. / Pastan, I. / Xia, D.
External linksJ. Biol. Chem. / PubMed:22787150
MethodsX-ray diffraction
Resolution1.749 - 2.65 Å
Structure data

PDB-4f33:
Crystal Structure of therapeutic antibody MORAb-009
Method: X-RAY DIFFRACTION / Resolution: 1.749 Å

PDB-4f3f:
Crystal Structure of Msln7-64 MORAb-009 FAB complex
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IgG / Antigen binding / Mesothelin / Antibody Fab / Recognize mesothelin

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