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Structure paper

TitleRoco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 10322-10327, Year 2012
Publish dateMay 4, 2012 (structure data deposition date)
AuthorsGilsbach, B.K. / Ho, F.Y. / Vetter, I.R. / van Haastert, P.J. / Wittinghofer, A. / Kortholt, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:22689969
MethodsX-ray diffraction
Resolution1.8 - 2.3 Å
Structure data

PDB-4f0f:
Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4f0g:
Crystal Structure of the Roco4 Kinase Domain from D. discoideum
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4f1m:
Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum.
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

PDB-4f1o:
Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4f1t:
Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-MG:
Unknown entry

ChemComp-H52:
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE

Source
  • dictyostelium discoideum (eukaryote)
KeywordsTRANSFERASE / SIGNALING PROTEIN / Protein Kinase / LRRK2 / ROCO / Kinase / ATP-binding / Nucleotide-binding / Serine/threonine-protein kinase / Parkinson disease / Signaling Protein/INHIBITOR / Signaling Protein-INHIBITOR complex

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