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Structure paper

TitleStructure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 3837-3851, Year 2012
Publish dateFeb 20, 2012 (structure data deposition date)
AuthorsChen, X. / Kopecky, D.J. / Mihalic, J. / Jeffries, S. / Min, X. / Heath, J. / Deignan, J. / Lai, S. / Fu, Z. / Guimaraes, C. ...Chen, X. / Kopecky, D.J. / Mihalic, J. / Jeffries, S. / Min, X. / Heath, J. / Deignan, J. / Lai, S. / Fu, Z. / Guimaraes, C. / Shen, S. / Li, S. / Johnstone, S. / Thibault, S. / Xu, H. / Cardozo, M. / Shen, W. / Walker, N. / Kayser, F. / Wang, Z.
External linksJ. Med. Chem. / PubMed:22458568
MethodsX-ray diffraction
Resolution2.6 - 2.95 Å
Structure data

PDB-4dt6:
Co-crystal structure of eIF4E with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4dum:
Co-crystal structure of eIF4E with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-6LI:
7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate)

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-HLI:
(4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid

Source
  • homo sapiens (human)
KeywordsTRANSLATION / CAP-binding protein / translation initiation factor / m7GTP

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