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Title | Design and preparation of a potent series of hydroxyethylamine containing beta-secretase inhibitors that demonstrate robust reduction of central beta-amyloid. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 9009-9024, Year 2012 |
Publish date | Jan 27, 2012 (structure data deposition date) |
Authors | Weiss, M.M. / Williamson, T. / Babu-Khan, S. / Bartberger, M.D. / Brown, J. / Chen, K. / Cheng, Y. / Citron, M. / Croghan, M.D. / Dineen, T.A. ...Weiss, M.M. / Williamson, T. / Babu-Khan, S. / Bartberger, M.D. / Brown, J. / Chen, K. / Cheng, Y. / Citron, M. / Croghan, M.D. / Dineen, T.A. / Esmay, J. / Graceffa, R.F. / Harried, S.S. / Hickman, D. / Hitchcock, S.A. / Horne, D.B. / Huang, H. / Imbeah-Ampiah, R. / Judd, T. / Kaller, M.R. / Kreiman, C.R. / La, D.S. / Li, V. / Lopez, P. / Louie, S. / Monenschein, H. / Nguyen, T.T. / Pennington, L.D. / Rattan, C. / San Miguel, T. / Sickmier, E.A. / Wahl, R.C. / Wen, P.H. / Wood, S. / Xue, Q. / Yang, B.H. / Patel, V.F. / Zhong, W. |
External links | J. Med. Chem. / PubMed:22468639 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-4dh6: |
Chemicals | ChemComp-IOD: ChemComp-GOL: ChemComp-0KN: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Bace-1 / Beta-Secretase / Aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |