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Structure paper

TitleStructural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 10472-10482, Year 2013
Publish dateJan 26, 2012 (structure data deposition date)
AuthorsYu, Z.H. / Xu, J. / Walls, C.D. / Chen, L. / Zhang, S. / Zhang, R. / Wu, L. / Wang, L. / Liu, S. / Zhang, Z.Y.
External linksJ. Biol. Chem. / PubMed:23457302
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4dgp:
The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4dgx:
LEOPARD Syndrome-Associated SHP2/Y279C mutant
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE

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