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Structure paper

TitleActive site profiling reveals coupling between domains in SRC-family kinases.
Journal, issue, pagesNat. Chem. Biol., Vol. 9, Page 43-50, Year 2013
Publish dateJan 25, 2012 (structure data deposition date)
AuthorsKrishnamurty, R. / Brigham, J.L. / Leonard, S.E. / Ranjitkar, P. / Larson, E.T. / Dale, E.J. / Merritt, E.A. / Maly, D.J.
External linksNat. Chem. Biol. / PubMed:23143416
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-4dgg:
c-SRC kinase domain in complex with RM-1-176
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-I76:
3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / tyrosine protein kinase / ATP-binding / kinase domain

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