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-Structure paper
Title | Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 5, Page 1049-, Year 2014 |
Publish date | Apr 24, 2014 (structure data deposition date) |
![]() | Buijnsters, P. / De Angelis, M. / Langlois, X. / Rombouts, F.J.R. / Sanderson, W. / Tresadern, G. / Ritchie, A. / Trabanco, A.A. / Vanhoof, G. / Roosbroeck, Y.V. / Andres, J. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.5 Å |
Structure data | ![]() PDB-4d08: ![]() PDB-4d09: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-Q2T: ![]() ChemComp-MG: ![]() ChemComp-HOH: ![]() ChemComp-788: |
Source |
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![]() | HYDROLASE / BINDING SITES / CATALYTIC DOMAIN / CYCLIC NUCLEOTIDE PHOSPHODIESTERASES / TYPE 2 / TYPE 4 / DISEASE MODELS / ANIMAL / DRUG EVALUATION / PRECLINICAL / PHOSPHODIESTERASE 2 INHIBITORS / PHOSPHODIESTERASE INHIBITORS / PROTEIN BINDING / STRUCTURE-ACTIVITY RELATIONSHIP |