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Structure paper

TitleStructure of the Btb Domain of Keap1 and its Interaction with the Triterpenoid Antagonist Cddo.
Journal, issue, pagesPlos One, Vol. 9, Page 98896-, Year 2014
Publish dateApr 7, 2014 (structure data deposition date)
AuthorsCleasby, A. / Yon, J. / Day, P.J. / Richardson, C. / Tickle, I.J. / Williams, P.A. / Callahan, J.F. / Carr, R. / Concha, N. / Kerns, J.K. ...Cleasby, A. / Yon, J. / Day, P.J. / Richardson, C. / Tickle, I.J. / Williams, P.A. / Callahan, J.F. / Carr, R. / Concha, N. / Kerns, J.K. / Qi, H. / Sweitzer, T. / Ward, P. / Davies, T.G.
External linksPlos One / PubMed:24896564
MethodsX-ray diffraction
Resolution2.35 - 2.8 Å
Structure data

PDB-4cxi:
BTB domain of KEAP1
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-4cxj:
BTB domain of KEAP1 C151W mutant
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4cxt:
BTB domain of KEAP1 in complex with CDDO
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SXJ:
(13alpha,18alpha)-2-cyano-3-hydroxy-12-oxooleana-2,9(11)-dien-28-oic acid

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / SIGNALING PROTEIN / BTB DOMAIN / KEAP1

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