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Structure paper

TitleDiscovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Journal, issue, pagesNat. Chem. Biol., Year 2021
Publish dateAug 9, 2013 (structure data deposition date)
AuthorsWang, L. / Shao, X. / Zhong, T. / Wu, Y. / Xu, A. / Sun, X. / Gao, H. / Liu, Y. / Lan, T. / Tong, Y. ...Wang, L. / Shao, X. / Zhong, T. / Wu, Y. / Xu, A. / Sun, X. / Gao, H. / Liu, Y. / Lan, T. / Tong, Y. / Tao, X. / Du, W. / Wang, W. / Chen, Y. / Li, T. / Meng, X. / Deng, H. / Yang, B. / He, Q. / Ying, M. / Rao, Y.
External linksNat. Chem. Biol. / PubMed:33664520
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4c13:
x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-UML:
Uridine 5'Diphospho N-acetyl muramoyl-L-Alanyl-D-Glutamyl-L-Lysine

ChemComp-PO4:
PHOSPHATE ION

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • staphylococcus aureus (bacteria)
KeywordsLIGASE / MURE

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