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Structure paper

TitleStructure and Function of Human Xylulokinase, an Enzyme with Important Roles in Carbohydrate Metabolism
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 1643-, Year 2013
Publish dateOct 1, 2012 (structure data deposition date)
AuthorsBunker, R.D. / Bulloch, E.M.M. / Dickson, J.M.J. / Loomes, K.M. / Baker, E.N.
External linksJ. Biol. Chem. / PubMed:23179721
MethodsX-ray diffraction
Resolution1.68 - 1.98 Å
Structure data

PDB-4bc2:
Crystal structure of human D-xylulokinase in complex with D-xylulose and adenosine diphosphate
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-4bc3:
Crystal structure of human D-xylulokinase
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-4bc4:
Crystal structure of human D-xylulokinase in complex with D-xylulose
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-4bc5:
Crystal structure of human D-xylulokinase in complex with inhibitor 5- deoxy-5-fluoro-D-xylulose
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-XUL:
D-XYLULOSE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-5FX:
5-deoxy-5-fluoro-D-xylulose

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / GLUCURONATE XYLULOKINASE PATHWAY / FGGY CARBOHYDRATE KINASE / INHIBITOR

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