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Structure paper

TitleStructural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
Journal, issue, pagesTo be Published
Publish dateAug 28, 2012 (structure data deposition date)
AuthorsSessa, F. / Villa, F.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.85 - 3 Å
Structure data

PDB-4b8l:
Aurora B kinase P353G mutant
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4b8m:
Aurora B kinase in complex with VX-680
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-A0P:
9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-9H-purin-6-amine

ChemComp-VX6:
CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsCELL CYCLE / CANCER

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