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Author
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IF

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Structure paper

TitleComplexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 230-, Year 2013
Publish dateJul 25, 2012 (structure data deposition date)
AuthorsLapkouski, M. / Tian, L. / Miller, J.T. / Le Grice, S.F.J. / Yang, W.
External linksNat. Struct. Mol. Biol. / PubMed:23314251
MethodsX-ray diffraction
Resolution3.3 - 5 Å
Structure data

PDB-4b3o:
Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-4b3p:
Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
Method: X-RAY DIFFRACTION / Resolution: 4.839 Å

PDB-4b3q:
Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
Method: X-RAY DIFFRACTION / Resolution: 5 Å

Chemicals

ChemComp-EFZ:
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE / medication, antiretroviral*YM

ChemComp-CA:
Unknown entry

ChemComp-NVP:
11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE / medication, antiretroviral*YM

Source
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsHYDROLASE/DNA/RNA / HYDROLASE-DNA-RNA COMPLEX / RNASE H / SUBUNIT INTERFACE / HYDROLASE/RNA/DNA / HYDROLASE-RNA-DNA COMPLEX / HYBRID

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