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-Structure paper
Title | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 6317-, Year 2013 |
Publish date | Sep 20, 2011 (structure data deposition date) |
![]() | Talapatra, S.K. / Anthony, N.G. / Mackay, S.P. / Kozielski, F. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.8 Å |
Structure data | ![]() PDB-4a1z: ![]() PDB-4a28: ![]() PDB-4as7: ![]() PDB-4b7b: ![]() PDB-4bxn: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-NO3: ![]() ChemComp-ADP: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-CO: ![]() ChemComp-CD: ![]() ChemComp-6LX: ![]() ChemComp-CA: |
Source |
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![]() | MOTOR PROTEIN / CELL CYCLE / MITOSIS |