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-Structure paper
Title | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 6317-, Year 2013 |
Publish date | Sep 20, 2011 (structure data deposition date) |
Authors | Talapatra, S.K. / Anthony, N.G. / Mackay, S.P. / Kozielski, F. |
External links | J. Med. Chem. / PubMed:23875972 |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.8 Å |
Structure data | PDB-4a1z: PDB-4a28: PDB-4as7: PDB-4b7b: PDB-4bxn: |
Chemicals | ChemComp-MG: ChemComp-NO3: ChemComp-ADP: ChemComp-HOH: ChemComp-CL: ChemComp-CO: ChemComp-CD: ChemComp-6LX: ChemComp-CA: |
Source |
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Keywords | MOTOR PROTEIN / CELL CYCLE / MITOSIS |