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Structure paper

TitleCrystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Journal, issue, pagesStructure, Vol. 20, Page 841-, Year 2012
Publish dateMar 11, 2012 (structure data deposition date)
AuthorsWarne, T. / Edwards, P.C. / Leslie, A.G. / Tate, C.G.
External linksStructure / PubMed:22579251
MethodsX-ray diffraction
Resolution2.3 - 3.2 Å
Structure data

PDB-4ami:
Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-4amj:
Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-G90:
2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile

ChemComp-2CV:
HEGA-10 / detergent*YM

ChemComp-HOH:
WATER

ChemComp-CVD:
(2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL

ChemComp-NA:
Unknown entry

Source
  • meleagris gallopavo (turkey)
KeywordsMEMBRANE PROTEIN / 7TMR BETA1-ADRENOCEPTOR / STABILISING MUTATIONS / BIASED AGONIST

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