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Structure paper

TitleDissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
Journal, issue, pagesChem. Biol., Vol. 19, Page 1300-, Year 2012
Publish dateJul 6, 2011 (structure data deposition date)
AuthorsVan Molle, I. / Thomann, A. / Buckley, D.L. / So, E.C. / Lang, S. / Crews, C.M. / Ciulli, A.
External linksChem. Biol. / PubMed:23102223
MethodsX-ray diffraction
Resolution1.73 - 2.79 Å
Structure data

PDB-3ztc:
pVHL54-213-EloB-EloC complex _ (2S,4R)-N-((1,1'-biphenyl)-4-ylmethyl)- 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2- carboxamide
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-3ztd:
pVHL54-213-EloB-EloC complex _ methyl 4-(((2S,4R)-4-hydroxy-1-(2-(3- methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamido)methyl)benzoate
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-4ajy:
von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-4awj:
pVHL:EloB:EloC complex, in complex with capped Hydroxyproline
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-TR0:
(4R)-N-(BIPHENYL-4-YLMETHYL)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-L-PROLINAMIDE

ChemComp-HOH:
WATER

ChemComp-ZTD:
METHYL 4-[({(4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-L-PROLYL}AMINO)METHYL]BENZOATE

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-V6F:
(4R)-1-acetyl-4-hydroxy-N-methyl-L-prolinamide

ChemComp-ACY:
ACETIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / TUMOUR SUPRESSOR PROTEIN / CHRONIC ANEAMIA TREATMENT / E3 UBIQUITIN LIGASE / PVHL E3 UBIQUITIN LIGASE / TRANSCRIPTION FACTOR / HYPOXIC SIGNALING / TUMOR SUPRESSOR

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