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Structure paper

TitleStructural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 7705-7710, Year 2012
Publish dateApr 29, 2008 (structure data deposition date)
AuthorsThangavelu, K. / Pan, C.Q. / Karlberg, T. / Balaji, G. / Uttamchandani, M. / Suresh, V. / Schuler, H. / Low, B.C. / Sivaraman, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:22538822
MethodsX-ray diffraction
Resolution2.2 - 2.7 Å
Structure data

PDB-3czd:
Crystal structure of human glutaminase in complex with L-glutamate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3voy:
Crystal structure of human glutaminase in apo form
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3voz:
Crystal structure of human glutaminase in complex with BPTES
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3vp0:
Crystal structure of human glutaminase in complex with L-glutamine
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3vp1:
Crystal structure of human glutaminase in complex with L-glutamate and BPTES
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3vp2:
Crystal structure of human glutaminase in complex with inhibitor 2
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3vp3:
Crystal structure of human glutaminase in complex with inhibitor 3
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3vp4:
Crystal structure of human glutaminase in complex with inhibitor 4
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-04A:
N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide)

ChemComp-GLN:
GLUTAMINE

ChemComp-BP0:
5,5'-(sulfanediyldiethane-2,1-diyl)bis(1,3,4-thiadiazol-2-amine)

ChemComp-BP8:
5,5'-pentane-1,5-diylbis(1,3,4-thiadiazol-2-amine)

ChemComp-BP9:
5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine)

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Glutamine / glutamate / kidney isoform / K-glutaminase / SGC / Structural Genomics Consortium / ANK repeat / Mitochondrion / Transit peptide / HYDROLASE/HYDROLASE INHIBTIOR / HYDROLASE-HYDROLASE INHIBTIOR complex / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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