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-Structure paper
Title | Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 7, Page 1830-1839, Year 2012 |
Publish date | Dec 17, 2011 (structure data deposition date) |
![]() | Thal, D.M. / Homan, K.T. / Chen, J. / Wu, E.K. / Hinkle, P.M. / Huang, Z.M. / Chuprun, J.K. / Song, J. / Gao, E. / Cheung, J.Y. ...Thal, D.M. / Homan, K.T. / Chen, J. / Wu, E.K. / Hinkle, P.M. / Huang, Z.M. / Chuprun, J.K. / Song, J. / Gao, E. / Cheung, J.Y. / Sklar, L.A. / Koch, W.J. / Tesmer, J.J. |
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Methods | X-ray diffraction |
Resolution | 2.07 Å |
Structure data | ![]() PDB-3v5w: |
Chemicals | ![]() ChemComp-8PR: ![]() ChemComp-MG: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor complex / Protein kinase / Beta propeller / RGS homology domain / Pleckstrin homology domain / Kinase / Signal transduction / Peripheral membrane protein / TRANSFERASE-TRANSFERASE INHIBITOR complex |