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TitleConversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 16609-16622, Year 2012
Publish dateDec 7, 2011 (structure data deposition date)
AuthorsChen, M. / Drury, J.E. / Christianson, D.W. / Penning, T.M.
External linksJ. Biol. Chem. / PubMed:22437839
MethodsX-ray diffraction
Resolution1.637 - 1.892 Å
Structure data

PDB-3uzw:
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+
Method: X-RAY DIFFRACTION / Resolution: 1.892 Å

PDB-3uzx:
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and epiandrosterone
Method: X-RAY DIFFRACTION / Resolution: 1.637 Å

PDB-3uzy:
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and 5beta-dihydrotestosterone
Method: X-RAY DIFFRACTION / Resolution: 1.832 Å

PDB-3uzz:
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and delta4-androstenedione
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-AOM:
5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL / hormone*YM

ChemComp-AOX:
(3Beta,5alpha)-3-Hydroxyandrostan-17-one / hormone*YM

ChemComp-BDT:
5-beta-DIHYDROTESTOSTERONE

ChemComp-TES:
TESTOSTERONE / hormone*YM

ChemComp-ASD:
4-ANDROSTENE-3-17-DIONE / hormone*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / ALDO-KETO REDUCTASE / STEROID AND BILE ACID METABOLISM / CATALYTIC TETRAD MUTANT / Tim Barrel

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