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TitleStructure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Journal, issue, pagesNature, Vol. 482, Page 547-551, Year 2012
Publish dateNov 16, 2011 (structure data deposition date)
AuthorsHaga, K. / Kruse, A.C. / Asada, H. / Yurugi-Kobayashi, T. / Shiroishi, M. / Zhang, C. / Weis, W.I. / Okada, T. / Kobilka, B.K. / Haga, T. / Kobayashi, T.
External linksNature / PubMed:22278061
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-3uon:
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-QNB:
(3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsSIGNALING PROTEIN/ANTAGONIST / G protein-coupled receptor / GPCR / acetylcholine receptor / SIGNALING PROTEIN-ANTAGONIST complex

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