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Structure paper

TitleCrystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 1801-1812, Year 2012
Publish dateAug 18, 2011 (structure data deposition date)
AuthorsOhto, U. / Usui, K. / Ochi, T. / Yuki, K. / Satow, Y. / Shimizu, T.
External linksJ. Biol. Chem. / PubMed:22128166
MethodsX-ray diffraction
Resolution1.79 - 1.8 Å
Structure data

PDB-3thc:
Crystal structure of human beta-galactosidase in complex with galactose
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3thd:
Crystal structure of human beta-galactosidase in complex with 1-deoxygalactonojirimycin
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-GAL:
beta-D-galactopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-DGJ:
(2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol / medication, Galafold*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / BETA-GALACTOSIDASE / TIM-BARREL DOMAIN / GLYCOSYL HYDROLASE / Glycosylation

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