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Structure paper

TitleWnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Journal, issue, pagesStructure, Vol. 19, Page 1433-1442, Year 2011
Publish dateJun 30, 2011 (structure data deposition date)
AuthorsBourhis, E. / Wang, W. / Tam, C. / Hwang, J. / Zhang, Y. / Spittler, D. / Huang, O.W. / Gong, Y. / Estevez, A. / Zilberleyb, I. ...Bourhis, E. / Wang, W. / Tam, C. / Hwang, J. / Zhang, Y. / Spittler, D. / Huang, O.W. / Gong, Y. / Estevez, A. / Zilberleyb, I. / Rouge, L. / Chiu, C. / Wu, Y. / Costa, M. / Hannoush, R.N. / Franke, Y. / Cochran, A.G.
External linksStructure / PubMed:21944579
MethodsX-ray diffraction
Resolution1.27 - 1.9 Å
Structure data

PDB-3sob:
The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3soq:
The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3sov:
The structure of a beta propeller domain in complex with peptide S
Method: X-RAY DIFFRACTION / Resolution: 1.27 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING/IMMUNE SYSTEM / Beta propeller / PROTEIN BINDING-IMMUNE SYSTEM complex / PROTEIN BINDING/Antagonist / PROTEIN BINDING-Antagonist complex

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