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Structure paper

TitleCrystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2''-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases.
Journal, issue, pagesBiochemistry, Vol. 50, Page 6237-6244, Year 2011
Publish dateJun 14, 2011 (structure data deposition date)
AuthorsShi, K. / Houston, D.R. / Berghuis, A.M.
External linksBiochemistry / PubMed:21678960
MethodsX-ray diffraction
Resolution1.8 - 2.15 Å
Structure data

PDB-3sg8:
Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3sg9:
Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Kanamycin A Complex
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-3sgc:
Crystal Structure of Apo Aminoglycoside-2''-Phosphotransferase Type IVa
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-TOY:
TOBRAMYCIN / antibiotic*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-KAN:
KANAMYCIN A / antibiotic*YM

Source
  • enterococcus casseliflavus (bacteria)
KeywordsTRANSFERASE/ANTIBIOTIC / Antibiotic resistance enzyme / Transferase / Aminoglycoside / Phosphorylation / TRANSFERASE-ANTIBIOTIC complex / Phosphotransferase

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