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TitleFocused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
Journal, issue, pagesScience, Vol. 333, Page 1593-1602, Year 2011
Publish dateJun 10, 2011 (structure data deposition date)
AuthorsWu, X. / Zhou, T. / Zhu, J. / Zhang, B. / Georgiev, I. / Wang, C. / Chen, X. / Longo, N.S. / Louder, M. / McKee, K. ...Wu, X. / Zhou, T. / Zhu, J. / Zhang, B. / Georgiev, I. / Wang, C. / Chen, X. / Longo, N.S. / Louder, M. / McKee, K. / O'Dell, S. / Perfetto, S. / Schmidt, S.D. / Shi, W. / Wu, L. / Yang, Y. / Yang, Z.Y. / Yang, Z. / Zhang, Z. / Bonsignori, M. / Crump, J.A. / Kapiga, S.H. / Sam, N.E. / Haynes, B.F. / Simek, M. / Burton, D.R. / Koff, W.C. / Doria-Rose, N.A. / Connors, M. / Mullikin, J.C. / Nabel, G.J. / Roederer, M. / Shapiro, L. / Kwong, P.D. / Mascola, J.R.
External linksScience / PubMed:21835983
MethodsX-ray diffraction
Resolution1.895 - 2 Å
Structure data

PDB-3se8:
Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120
Method: X-RAY DIFFRACTION / Resolution: 1.895 Å

PDB-3se9:
Crystal structure of broadly and potently neutralizing antibody VRC-PG04 in complex with HIV-1 gp120
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV / GP120 / ANTIBODY / VRC03 / NEUTRALIZATION / VACCINE / ENVELOPE GLYCOPROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / VRC-PG04

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