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-Structure paper
Title | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 1648-1658, Year 2009 |
Publish date | Feb 2, 2009 (structure data deposition date) |
![]() | Bello, A.M. / Konforte, D. / Poduch, E. / Furlonger, C. / Wei, L. / Liu, Y. / Lewis, M. / Pai, E.F. / Paige, C.J. / Kotra, L.P. |
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Methods | X-ray diffraction |
Resolution | 1.4 - 1.7 Å |
Structure data | ![]() PDB-3g3d: ![]() PDB-3g3m: ![]() PDB-3s9y: |
Chemicals | ![]() ChemComp-5FU: ![]() ChemComp-GOL: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-FNU: ![]() ChemComp-PGE: ![]() ChemComp-PEG: ![]() ChemComp-P6G: |
Source |
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![]() | LYASE / UMP synthase / c-terminal Domain / Orotidine 5'-monophosphate Decarboxylase / human / 5-fluoro-6-azido-UMP / Decarboxylase / Disease mutation / Glycosyltransferase / Multifunctional enzyme / Phosphoprotein / Pyrimidine biosynthesis / Transferase / 5-fluoro-6-iodo-UMP / Alternative splicing / Polymorphism / P. falciparum / 5-fluoro-6-amino-UMP |