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TitleStructural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 18756-18765, Year 2011
Publish dateNov 23, 2010 (structure data deposition date)
AuthorsAertgeerts, K. / Skene, R. / Yano, J. / Sang, B.C. / Zou, H. / Snell, G. / Jennings, A. / Iwamoto, K. / Habuka, N. / Hirokawa, A. ...Aertgeerts, K. / Skene, R. / Yano, J. / Sang, B.C. / Zou, H. / Snell, G. / Jennings, A. / Iwamoto, K. / Habuka, N. / Hirokawa, A. / Ishikawa, T. / Tanaka, T. / Miki, H. / Ohta, Y. / Sogabe, S.
External linksJ. Biol. Chem. / PubMed:21454582
MethodsX-ray diffraction
Resolution1.5 - 2.25 Å
Structure data

PDB-3poz:
EGFR Kinase domain complexed with tak-285
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3pp0:
Crystal Structure of the Kinase domain of Human HER2 (erbB2).
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-03P:
N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide

ChemComp-HOH:
WATER

ChemComp-03Q:
2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / KINASE DOMAIN / ANTI-ONCOGENE / ATP-BINDING / CELL CYCLE / DISEASE MUTATION / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / RECEPTOR / SECRETED / TRANSFERASE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE / TRANSFERASE-TRANSFERASE INHIBITOR complex / TYROSINE KINASE INHIBITOR

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