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Author
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IF

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Structure paper

TitleReplication infidelity via a mismatch with Watson-Crick geometry.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 1862-1867, Year 2011
Publish dateNov 17, 2010 (structure data deposition date)
AuthorsBebenek, K. / Pedersen, L.C. / Kunkel, T.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:21233421
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-3pml:
crystal structure of a polymerase lambda variant with a dGTP analog opposite a templating T
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3pmn:
ternary crystal structure of polymerase lambda variant with a GT mispair at the primer terminus with Mn2+ in the active site
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3pnc:
Ternary crystal structure of a polymerase lambda variant with a GT mispair at the primer terminus and sodium at catalytic metal site
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-1GC:
2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsLYASE / TRANSFERASE/DNA / PROTEIN-DNA COMPLEX / TRANSFERASE / DNA / TRANSFERASE-DNA complex

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