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Structure paper

TitleMolecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 3315-3322, Year 2011
Publish dateJan 13, 2010 (structure data deposition date)
AuthorsArtz, J.D. / Wernimont, A.K. / Dunford, J.E. / Schapira, M. / Dong, A. / Zhao, Y. / Lew, J. / Russell, R.G. / Ebetino, F.H. / Oppermann, U. / Hui, R.
External linksJ. Biol. Chem. / PubMed:21084289
MethodsX-ray diffraction
Resolution2.1 - 2.5 Å
Structure data

PDB-3ldw:
Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

PDB-3mav:
Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3ph7:
Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZOL:
ZOLEDRONIC ACID / medication*YM

ChemComp-IPE:
3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GRG:
GERANYLGERANYL DIPHOSPHATE

Source
  • plasmodium vivax (malaria parasite P. vivax)
KeywordsTRANSFERASE / malaria / farnesyl pyrophosphate synthase diphosphate / lyase / structural genomics / Isoprene biosynthesis / Structural Genomics Consortium / SGC / PLASMODIUM VIVAX FARNESYL PYROPHOSPHATE SYNTHASE / PV092040

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