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TitleStructure and function of an irreversible agonist-beta(2) adrenoceptor complex
Journal, issue, pagesNature, Vol. 469, Page 236-240, Year 2011
Publish dateOct 24, 2010 (structure data deposition date)
AuthorsRosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.J. / Devree, B.T. / Sunahara, R.K. ...Rosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.J. / Devree, B.T. / Sunahara, R.K. / Chae, P.S. / Gellman, S.H. / Dror, R.O. / Shaw, D.E. / Weis, W.I. / Caffrey, M. / Gmeiner, P. / Kobilka, B.K.
External linksNature / PubMed:21228876
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-3pds:
Irreversible Agonist-Beta2 Adrenoceptor Complex
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-ERC:
8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one

ChemComp-CLR:
CHOLESTEROL

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsMembrane Protein/Hydrolase / GPCR / signaling / beta adrenergic agonist / fusion protein / Membrane Protein-Hydrolase complex

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