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Structure paper

TitleInhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds
Journal, issue, pagesChemmedchem, Vol. 6, Page 759-764, Year 2011
Publish dateOct 23, 2010 (structure data deposition date)
AuthorsChang, K.-H. / King, O.N.F. / Tumber, A. / Woon, E.C. / Heightman, T.D. / McDonough, M.A. / Schofield, C.J. / Rose, N.R.
External linksChemmedchem / PubMed:21412984
MethodsX-ray diffraction
Resolution1.989 Å
Structure data

PDB-3pdq:
Crystal structure of JMJD2A complexed with bipyridyl inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.989 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-ZN:
Unknown entry

ChemComp-KC6:
4'-[(2-aminoethyl)carbamoyl]-2,2'-bipyridine-4-carboxylic acid

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOxidoreductase/Oxidoreductase inhibitor / jmjC Domain / Oxidoreductase / Chromatin Regulator / Dioxygenase / Transcription / Iron / 2-oxoglutarate / alpha-ketoglutarate / Demethylation / Nucleus / Oxidoreductase-Oxidoreductase inhibitor complex

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