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TitleDiscovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 492-496, Year 2011
Publish dateSep 24, 2010 (structure data deposition date)
AuthorsLuckhurst, C.A. / Stein, L.A. / Furber, M. / Webb, N. / Ratcliffe, M.J. / Allenby, G. / Botterell, S. / Tomlinson, W. / Martin, B. / Walding, A.
External linksBioorg. Med. Chem. Lett. / PubMed:21094606
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-3oz0:
PPAR Delta in complex with azppard02
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-3OZ:
[4-({(1S)-1-[(2,4-dichlorophenyl)carbamoyl]-1,3-dihydro-2H-isoindol-2-yl}methyl)-2-methylphenoxy]acetic acid

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/TRANSCRIPTION REGULATOR / TRANSCRIPTION FACTOR / TRANSCRIPTION / NUCLEAR RECEPTOR FOLD / TRANSCRIPTION REGULATION / TRANSCRIPTION-TRANSCRIPTION REGULATOR complex

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