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TitleClinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Journal, issue, pagesNature, Vol. 467, Page 596-599, Year 2010
Publish dateAug 16, 2010 (structure data deposition date)
AuthorsBollag, G. / Hirth, P. / Tsai, J. / Zhang, J. / Ibrahim, P.N. / Cho, H. / Spevak, W. / Zhang, C. / Zhang, Y. / Habets, G. ...Bollag, G. / Hirth, P. / Tsai, J. / Zhang, J. / Ibrahim, P.N. / Cho, H. / Spevak, W. / Zhang, C. / Zhang, Y. / Habets, G. / Burton, E.A. / Wong, B. / Tsang, G. / West, B.L. / Powell, B. / Shellooe, R. / Marimuthu, A. / Nguyen, H. / Zhang, K.Y. / Artis, D.R. / Schlessinger, J. / Su, F. / Higgins, B. / Iyer, R. / D'Andrea, K. / Koehler, A. / Stumm, M. / Lin, P.S. / Lee, R.J. / Grippo, J. / Puzanov, I. / Kim, K.B. / Ribas, A. / McArthur, G.A. / Sosman, J.A. / Chapman, P.B. / Flaherty, K.T. / Xu, X. / Nathanson, K.L. / Nolop, K.
External linksNature / PubMed:20823850
MethodsX-ray diffraction
Resolution2.45 Å
Structure data

PDB-3og7:
B-Raf Kinase V600E oncogenic mutant in complex with PLX4032
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-032:
N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / B-Raf / BRAF / PROTO-ONCOGENE / V600E / Kinase / TRANSFERASE / transferase-transferase inhibitor complex

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