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Structure paper

TitleMolecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Journal, issue, pagesCell Res., Vol. 20, Page 1188-1200, Year 2010
Publish dateMar 24, 2010 (structure data deposition date)
AuthorsYang, B. / Zhong, C. / Peng, Y. / Lai, Z. / Ding, J.
External linksCell Res. / PubMed:20975740
MethodsX-ray diffraction
Resolution2.8 - 3.41 Å
Structure data

PDB-3map:
Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-3mar:
Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP
Method: X-RAY DIFFRACTION / Resolution: 3.41 Å

PDB-3mas:
Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-ICT:
ISOCITRIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / isocitrate dehydrogenase / nicotinamide adenine dinucleotide phosphate / Rossmann fold

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