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TitleCrystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
Journal, issue, pagesJ. Virol., Vol. 84, Page 8098-8110, Year 2010
Publish dateFeb 11, 2010 (structure data deposition date)
AuthorsPancera, M. / McLellan, J.S. / Wu, X. / Zhu, J. / Changela, A. / Schmidt, S.D. / Yang, Y. / Zhou, T. / Phogat, S. / Mascola, J.R. / Kwong, P.D.
External linksJ. Virol. / PubMed:20538861
MethodsX-ray diffraction
Resolution2.37 - 3.97 Å
Structure data

PDB-3lrs:
Structure of PG16, an antibody with broad and potent neutralization of HIV-1
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-3mme:
Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1
Method: X-RAY DIFFRACTION / Resolution: 3.97 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / neutralizing antibodies / long CDRH3 / HIV-1

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