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-Structure paper
Title | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 2837-2842, Year 2010 |
Publish date | Feb 2, 2010 (structure data deposition date) |
![]() | Cumming, J. / Babu, S. / Huang, Y. / Carrol, C. / Chen, X. / Favreau, L. / Greenlee, W. / Guo, T. / Kennedy, M. / Kuvelkar, R. ...Cumming, J. / Babu, S. / Huang, Y. / Carrol, C. / Chen, X. / Favreau, L. / Greenlee, W. / Guo, T. / Kennedy, M. / Kuvelkar, R. / Le, T. / Li, G. / McHugh, N. / Orth, P. / Ozgur, L. / Parker, E. / Saionz, K. / Stamford, A. / Strickland, C. / Tadesse, D. / Voigt, J. / Zhang, L. / Zhang, Q. |
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Methods | X-ray diffraction |
Resolution | 1.79 - 2.05 Å |
Structure data | ![]() PDB-3lnk: ![]() PDB-3lpi: ![]() PDB-3lpj: ![]() PDB-3lpk: |
Chemicals | ![]() ChemComp-74A: ![]() ChemComp-TLA: ![]() ChemComp-HOH: ![]() ChemComp-Z74: ![]() ChemComp-Z75: ![]() ChemComp-Z76: |
Source |
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![]() | HYDROLASE / Alzheimer's / BACE1 / Alternative splicing / Aspartyl protease / Disulfide bond / Endoplasmic reticulum / Endosome / Glycoprotein / Golgi apparatus / Membrane / Polymorphism / Protease / Transmembrane / Zymogen |