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Structure paper

TitleStructural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
Journal, issue, pagesJ. Virol., Vol. 84, Page 7625-7633, Year 2010
Publish dateFeb 4, 2010 (structure data deposition date)
AuthorsSu, H.P. / Yan, Y. / Prasad, G.S. / Smith, R.F. / Daniels, C.L. / Abeywickrema, P.D. / Reid, J.C. / Loughran, H.M. / Kornienko, M. / Sharma, S. ...Su, H.P. / Yan, Y. / Prasad, G.S. / Smith, R.F. / Daniels, C.L. / Abeywickrema, P.D. / Reid, J.C. / Loughran, H.M. / Kornienko, M. / Sharma, S. / Grobler, J.A. / Xu, B. / Sardana, V. / Allison, T.J. / Williams, P.D. / Darke, P.L. / Hazuda, D.J. / Munshi, S.
External linksJ. Virol. / PubMed:20484498
MethodsX-ray diffraction
Resolution2.23 - 2.8 Å
Structure data

PDB-3lp0:
HIV-1 reverse transcriptase with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-3lp1:
HIV-1 reverse transcriptase with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-3lp2:
HIV-1 reverse transcriptase with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-3lp3:
p15 HIV RNaseH domain with inhibitor MK3
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-LP7:
ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

ChemComp-NVP:
11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE / medication, antiretroviral*YM

ChemComp-HOH:
WATER

ChemComp-LP8:
3-cyclopentyl-1,4-dihydroxy-1,8-naphthyridin-2(1H)-one

ChemComp-LP9:
3-[4-(diethylamino)phenoxy]-6-(ethoxycarbonyl)-5,8-dihydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-1-ium

Source
  • human immunodeficiency virus type 1
KeywordsTRANSFERASE/HYDROLASE / Reverse Transcriptase / RNase H / HIV / AIDS / DNA-directed DNA polymerase / endonuclease / Host cytoplasm / Host nucleus / Host-virus interaction / Hydrolase / Magnesium / Metal-binding / Multifunctional enzyme / Nuclease / Nucleotidyltransferase / RNA-binding / RNA-directed DNA polymerase / Transferase / Viral nucleoprotein / Virion / TRANSFERASE-HYDROLASE complex / Capsid maturation / DNA integration / Host membrane / Membrane / Myristate / Aspartyl protease / Protease / VIRAL PROTEIN

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