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-Structure paper
Title | Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. |
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Journal, issue, pages | J. Virol., Vol. 84, Page 7625-7633, Year 2010 |
Publish date | Feb 4, 2010 (structure data deposition date) |
![]() | Su, H.P. / Yan, Y. / Prasad, G.S. / Smith, R.F. / Daniels, C.L. / Abeywickrema, P.D. / Reid, J.C. / Loughran, H.M. / Kornienko, M. / Sharma, S. ...Su, H.P. / Yan, Y. / Prasad, G.S. / Smith, R.F. / Daniels, C.L. / Abeywickrema, P.D. / Reid, J.C. / Loughran, H.M. / Kornienko, M. / Sharma, S. / Grobler, J.A. / Xu, B. / Sardana, V. / Allison, T.J. / Williams, P.D. / Darke, P.L. / Hazuda, D.J. / Munshi, S. |
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Methods | X-ray diffraction |
Resolution | 2.23 - 2.8 Å |
Structure data | ![]() PDB-3lp0: ![]() PDB-3lp1: ![]() PDB-3lp2: ![]() PDB-3lp3: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-LP7: ![]() ChemComp-NVP: ![]() ChemComp-HOH: ![]() ChemComp-LP8: ![]() ChemComp-LP9: |
Source |
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![]() | TRANSFERASE/HYDROLASE / Reverse Transcriptase / RNase H / HIV / AIDS / DNA-directed DNA polymerase / endonuclease / Host cytoplasm / Host nucleus / Host-virus interaction / Hydrolase / Magnesium / Metal-binding / Multifunctional enzyme / Nuclease / Nucleotidyltransferase / RNA-binding / RNA-directed DNA polymerase / Transferase / Viral nucleoprotein / Virion / TRANSFERASE-HYDROLASE complex / Capsid maturation / DNA integration / Host membrane / Membrane / Myristate / Aspartyl protease / Protease / VIRAL PROTEIN |