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Structure paper

TitleCrystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
Journal, issue, pagesBiochem. J., Vol. 430, Page 425-437, Year 2010
Publish dateJan 5, 2010 (structure data deposition date)
AuthorsLee, C.C. / Jia, Y. / Li, N. / Sun, X. / Ng, K. / Ambing, E. / Gao, M.Y. / Hua, S. / Chen, C. / Kim, S. ...Lee, C.C. / Jia, Y. / Li, N. / Sun, X. / Ng, K. / Ambing, E. / Gao, M.Y. / Hua, S. / Chen, C. / Kim, S. / Michellys, P.Y. / Lesley, S.A. / Harris, J.L. / Spraggon, G.
External linksBiochem. J. / PubMed:20632993
MethodsX-ray diffraction
Resolution1.8 - 2.1 Å
Structure data

PDB-3l9p:
Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3lcs:
Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-3lct:
Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase domain / ATP-binding / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / Receptor / Transmembrane / Tyrosine-protein kinase / kinase catalytic domain

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