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Structure paper

TitleStructures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Journal, issue, pagesCell Cycle, Vol. 9, Page 1104-1111, Year 2010
Publish dateJan 8, 2010 (structure data deposition date)
AuthorsPopowicz, G.M. / Czarna, A. / Wolf, S. / Wang, K. / Wang, W. / Domling, A. / Holak, T.A.
External linksCell Cycle / PubMed:20237429
MethodsX-ray diffraction
Resolution1.5 - 2.3 Å
Structure data

PDB-3lbj:
Structure of human MDMX protein in complex with a small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3lbk:
Structure of human MDM2 protein in complex with a small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3lbl:
Structure of human MDM2 protein in complex with Mi-63-analog
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-WW8:
N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-K23:
6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid

ChemComp-MI6:
(2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / MDMX / MDM2 / p53 / inhibitor / Alternative splicing / Nucleus / Polymorphism / Zinc-finger / LIGASE / Cytoplasm / Phosphoprotein / Proto-oncogene / Ubl conjugation / Ubl conjugation pathway

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