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Structure paper

TitleStructural basis of HIV-1 resistance to AZT by excision.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 1202-1209, Year 2010
Publish dateNov 7, 2009 (structure data deposition date)
AuthorsTu, X. / Das, K. / Han, Q. / Bauman, J.D. / Clark, A.D. / Hou, X. / Frenkel, Y.V. / Gaffney, B.L. / Jones, R.A. / Boyer, P.L. ...Tu, X. / Das, K. / Han, Q. / Bauman, J.D. / Clark, A.D. / Hou, X. / Frenkel, Y.V. / Gaffney, B.L. / Jones, R.A. / Boyer, P.L. / Hughes, S.H. / Sarafianos, S.G. / Arnold, E.
External linksNat. Struct. Mol. Biol. / PubMed:20852643
MethodsX-ray diffraction
Resolution2.65 - 3.65 Å
Structure data

PDB-3kle:
Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-3klf:
Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-3klg:
Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N)
Method: X-RAY DIFFRACTION / Resolution: 3.65 Å

PDB-3klh:
Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3kli:
Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZP4:
[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus type 1
  • mus musculus (house mouse)
KeywordsTRANSFERASE/DNA / AZT RESISTANCE MECHANISM / HIV-1 / REVERSE TRANSCRIPTASE / RT / AZT / RESISTANCE MUTATIONS / P51/P66 / NUCLEOSIDE INHIBITOR / NUCLEOTIDE EXCISION / THYMIDINE ANALOG MUTATIONS / AIDS / HIV / DNA POLYMERASE / NRTI / NRTI RESISTANCE / AZTPPPPA / AZTP4A / AZT ADENOSINE DINUCLEOSIDE TETRAPHOSPHATE / DNA-DIRECTED DNA POLYMERASE / ENDONUCLEASE / HYDROLASE / MAGNESIUM / METAL-BINDING / MULTIFUNCTIONAL ENZYME / MYRISTATE / NUCLEASE / RNA-DIRECTED DNA POLYMERASE / TRANSFERASE / TRANSFERASE-DNA COMPLEX / HIV-1 REVERSE TRANSCRIPTASE / WILD-TYPE / AZT RESISTANCE MUTATIONS / NUCELEOSIDE INHIBITOR / DINUCLEOSIDE TETRAPHOSPHATE / AZT EXCISION / AZT RESISTANCE / RESISTANCE MECHANISM / MYRISTATE NUCLEASE / HETERO DIMER / DNA RECOMBINATION

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