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-Structure paper
Title | Structural basis of HIV-1 resistance to AZT by excision. |
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Journal, issue, pages | Nat. Struct. Mol. Biol., Vol. 17, Page 1202-1209, Year 2010 |
Publish date | Nov 7, 2009 (structure data deposition date) |
Authors | Tu, X. / Das, K. / Han, Q. / Bauman, J.D. / Clark, A.D. / Hou, X. / Frenkel, Y.V. / Gaffney, B.L. / Jones, R.A. / Boyer, P.L. ...Tu, X. / Das, K. / Han, Q. / Bauman, J.D. / Clark, A.D. / Hou, X. / Frenkel, Y.V. / Gaffney, B.L. / Jones, R.A. / Boyer, P.L. / Hughes, S.H. / Sarafianos, S.G. / Arnold, E. |
External links | Nat. Struct. Mol. Biol. / PubMed:20852643 |
Methods | X-ray diffraction |
Resolution | 2.65 - 3.65 Å |
Structure data | PDB-3kle: PDB-3klf: PDB-3klg: PDB-3klh: PDB-3kli: |
Chemicals | ChemComp-MG: ChemComp-ZP4: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/DNA / AZT RESISTANCE MECHANISM / HIV-1 / REVERSE TRANSCRIPTASE / RT / AZT / RESISTANCE MUTATIONS / P51/P66 / NUCLEOSIDE INHIBITOR / NUCLEOTIDE EXCISION / THYMIDINE ANALOG MUTATIONS / AIDS / HIV / DNA POLYMERASE / NRTI / NRTI RESISTANCE / AZTPPPPA / AZTP4A / AZT ADENOSINE DINUCLEOSIDE TETRAPHOSPHATE / DNA-DIRECTED DNA POLYMERASE / ENDONUCLEASE / HYDROLASE / MAGNESIUM / METAL-BINDING / MULTIFUNCTIONAL ENZYME / MYRISTATE / NUCLEASE / RNA-DIRECTED DNA POLYMERASE / TRANSFERASE / TRANSFERASE-DNA COMPLEX / HIV-1 REVERSE TRANSCRIPTASE / WILD-TYPE / AZT RESISTANCE MUTATIONS / NUCELEOSIDE INHIBITOR / DINUCLEOSIDE TETRAPHOSPHATE / AZT EXCISION / AZT RESISTANCE / RESISTANCE MECHANISM / MYRISTATE NUCLEASE / HETERO DIMER / DNA RECOMBINATION |