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Title | Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor |
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Journal, issue, pages | Chemmedchem, Vol. 5, Page 255-267, Year 2010 |
Publish date | Oct 8, 2009 (structure data deposition date) |
Authors | Coumar, M.S. / Tsai, M.T. / Chu, C.Y. / Uang, B.J. / Lin, W.H. / Chang, C.Y. / Chang, T.Y. / Leou, J.S. / Teng, C.H. / Wu, J.S. ...Coumar, M.S. / Tsai, M.T. / Chu, C.Y. / Uang, B.J. / Lin, W.H. / Chang, C.Y. / Chang, T.Y. / Leou, J.S. / Teng, C.H. / Wu, J.S. / Fang, M.Y. / Chen, C.H. / Hsu, J.T. / Wu, S.Y. / Chao, Y.S. / Hsieh, H.P. |
External links | Chemmedchem / PubMed:20039358 |
Methods | X-ray diffraction |
Resolution | 2.35 Å |
Structure data | PDB-3k5u: |
Chemicals | ChemComp-PFQ: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Aurora kinase inhibitors / Virtual screening / X-ray co-crystal analysis / Structure-based drug design (SBDD) / H-bonding / ATP-binding site / Cell cycle / Cytoskeleton / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |