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TitleDiscovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 6193-6196, Year 2009
Publish dateSep 2, 2009 (structure data deposition date)
AuthorsWagner, J. / von Matt, P. / Sedrani, R. / Albert, R. / Cooke, N. / Ehrhardt, C. / Geiser, M. / Rummel, G. / Stark, W. / Strauss, A. ...Wagner, J. / von Matt, P. / Sedrani, R. / Albert, R. / Cooke, N. / Ehrhardt, C. / Geiser, M. / Rummel, G. / Stark, W. / Strauss, A. / Cowan-Jacob, S.W. / Beerli, C. / Weckbecker, G. / Evenou, J.P. / Zenke, G. / Cottens, S.
External linksJ. Med. Chem. / PubMed:19827831
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-3iw4:
Crystal structure of PKC alpha in complex with NVP-AEB071
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-LW4:
3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / ATP-binding / Cell membrane / Membrane / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Phosphoprotein / Serine/threonine-protein kinase / Zinc-finger

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