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TitleSubstrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.
Journal, issue, pagesBiochemistry, Vol. 49, Page 1541-1548, Year 2010
Publish dateAug 5, 2009 (structure data deposition date)
AuthorsBalogh, L.M. / Le Trong, I. / Kripps, K.A. / Shireman, L.M. / Stenkamp, R.E. / Zhang, W. / Mannervik, B. / Atkins, W.M.
External linksBiochemistry / PubMed:20085333
MethodsX-ray diffraction
Resolution1.97 - 2.2 Å
Structure data

PDB-3ik7:
Human glutathione transferase a4-4 with GSDHN
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-3ik9:
Human GST A1-1-GIMF with GSDHN
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-BOB:
(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Human GST A4-4 / enzyme / Cytoplasm / Polymorphism / human GST A1-1 GIMF

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