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Structure paper

TitleThe active conformation of human glucokinase is not altered by allosteric activators
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 67, Page 929-935, Year 2011
Publish dateNov 14, 2008 (structure data deposition date)
AuthorsPetit, P. / Antoine, M. / Ferry, G. / Boutin, J.A. / Lagarde, A. / Gluais, L. / Vincentelli, R. / Vuillard, L.
External linksActa Crystallogr. ,Sect. D / PubMed:22101819
MethodsX-ray diffraction
Resolution1.5 - 2.4 Å
Structure data

PDB-3f9m:
Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3fgu:
Catalytic complex of Human Glucokinase
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-3id8:
Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3idh:
Human pancreatic glucokinase in complex with glucose
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

PDB-4no7:
Human Glucokinase in complex with a nanomolar activator.
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-MRK:
2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE

ChemComp-HOH:
WATER

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-2N8:
(2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Glucokinase / Hexokinase IV / ATP-binding / Diabetes mellitus / Disease mutation / Glycolysis / Kinase / Nucleotide-binding / TRANSFERASE/TRANSFERASE ACTIVATOR / pancreas / TRANSFERASE-TRANSFERASE ACTIVATOR complex

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