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TitleDeveloping dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Journal, issue, pagesBiochemistry, Vol. 48, Page 8624-8635, Year 2009
Publish dateJun 29, 2009 (structure data deposition date)
AuthorsWang, Y. / Monzingo, A.F. / Hu, S. / Schaller, T.H. / Robertus, J.D. / Fast, W.
External linksBiochemistry / PubMed:19663506
MethodsX-ray diffraction
Resolution1.898 - 2.03 Å
Structure data

PDB-3i2e:
Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (DDAH-1)
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-3i4a:
Crystal structure of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) in complex with N5-(1-iminopropyl)-L-ornithine
Method: X-RAY DIFFRACTION / Resolution: 1.898 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-LN5:
N5-(1-iminopropyl)-L-ornithine

Source
  • homo sapiens (human)
KeywordsHYDROLASE / DDAH / NITRIC OXIDE SYNTHASE REGULATOR / Metal-binding / Zinc / NITRIC OXIDE SYNTHASE REGULATION

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