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-Structure paper
Title | Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays |
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Journal, issue, pages | Biochemistry, Vol. 48, Page 10743-10751, Year 2009 |
Publish date | Jun 16, 2009 (structure data deposition date) |
![]() | Godemann, R. / Madden, J. / Kramer, J. / Smith, M.A. / Fritz, U. / Hesterkamp, T. / Barker, J. / Hoeppner, S. / Hallett, D. / Cesura, A. ...Godemann, R. / Madden, J. / Kramer, J. / Smith, M.A. / Fritz, U. / Hesterkamp, T. / Barker, J. / Hoeppner, S. / Hallett, D. / Cesura, A. / Ebneth, A. / Kemp, J. |
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Methods | X-ray diffraction |
Resolution | 2.26 - 2.48 Å |
Structure data | ![]() PDB-3hvg: ![]() PDB-3hw1: |
Chemicals | ![]() ChemComp-EV0: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-EV2: |
Source |
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![]() | HYDROLASE / PROTEASE / ALZHEIMER'S DISEASE / ASPARTIC PROTEASE / ASPARTYL PROTEASE / BASE / BETA-SECRETASE / GLYCOPROTEIN / MEMAPSIN 2 / Amyloid Precursor Protein Secretases / Aspartic Endopeptidases / fragment-based drug design / Fluorescence polarisation / Disulfide bond / Transmembrane / Zymogen |